Huntington’s Chorea Essay

1479 words - 6 pages

This paper will research the genetic disease Huntington’s Chorea. This paper will look at the main causes of the disease, what the main effects/symptoms of the disease are, where the disease is mainly found, if there is any cure/ treatment for the disease, ands what research is going on about the disease. In the greek language, chorea means “to dance” (Huntington’s Chorea, 2007). This term help describe what a person with Huntington’s goes through. According to Huntington’s disease (n.d.), a person may experience a handful of symptoms before they actually experience motor problems and other symptoms. All the symptoms will be covered in this paper. This paper will look at all the items listed above, as well as delve deeper into the disease Huntington’s Chorea.

The patient is middle aged. Through test and personal experience, he knows he has Huntington’s disease. He slowly starts developing symptoms of Huntington’s. He begins experiencing clumsiness. Then slowly he starts hallucinating. He starts losing all sense of awareness. Then, he loses his motor abilities. He can barely do anything for himself. This is accompanied by consistent seizures. After all the pain and suffering he has been through, he is awarded with death (Huntington’s disease, n.d.). As the early physician George Huntington stated, "the hapless sufferer is but a quivering wreck of his former self"(Huntington’s chorea, 2007). Early in time, people did not know what caused Huntington’s disease. They just knew that if one of their family members had it, there was no hope for them. They didn’t even bother to go to a doctor or physician. They knew that ultimately, the person would die a painful death. Only recently in the 20th century have scientists began to understand Huntington’s disease, as what causes it and how it is passed on. Yet, there is still no cure, as people still continue to suffer (Huntington’s chorea, 2007).
Huntington’s Disease is caused by a gene called HTT. Although humans know this gene exists, they do not know it’s full purpose. The HTT gene is located on the fourth chromosome on the small arm. They know the gene produces a protein called Huntington’s, which helps development before human birth. This protein is found in all the tissues of the human body, but with the most concentration found in the brain. The HTT has a DNA segment called the Cytosine, Adenine, and Guanine (CAG) repeat. The CAG segment comes up multiple times in a row. In normal human beings, the CAG segment is repeated ten to thirty-five times within the gene. But if a genetic mutation called CAG trinucleotide repeat expansion (CAGTRE) occurs, then the person gets Huntington’s disease (HTT, 2014).
Huntington’s Disease caused CAG to repeat thirty to one hundred and fifty times. This causes the proteins that are produced to be very long. Because of their length, the proteins all congregate together; and then the travel to the nucleus of the brain, where they prohibit the production of...

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