What Is Translational Bioinformatics? Essay

1715 words - 7 pages

Translational bioinformatics is a newly emerging field of informatics which defines as the development and application of informatics methods to optimize the transformation of increasingly massive biomedical data into practicable knowledge and novel technologies which can improve human health and diseases. There is a tremendous progress in scientific discovery since the foundation of double helix structure. However, it has not translated much into practical health benefit and has become a rate-limiting step for clinical application. Such phenomenon could be due to several barriers, one of which is the connection of molecular entities to clinical entities. There is a paradigm shift in biology where programs are focused upon the development and delivery of genomic and personalized medicine therefore the need for high-throughput and integrative approaches to assemble, manage and analyse the rapidly growing heterogeneous data sets has become imperative (Altman, 2012). As the world is in a new generation of information age, the incorporation of informatics into scientific studies becomes inevitable, leading to the development, advancement and application of translational bioinformatics. This essay will discuss the extent to which the development of translational bioinformatics in medical field can be the next game changer in medicine.
Translational bioinformatics have been greatly utilized in various newly emerging fields, for instances, biomarkers, systems biology and pharmacogenomics. The studies of biomarkers, systems biology and pharmacogenomics enable comprehensive understanding of diseases and empower scientists and clinicians to design individualized strategies to bring the right drugs with the right dosages to the right people at the right time via the right route due to genetic variation between individuals. These approaches help to minimize adverse effects, overcome therapeutic resistance, for instance, methicillin-resistant Staphylococcus aureus, as well as improve communication among various multidisciplinary groups. However, one of the most significant hindrances in the application of personalized medicine is the translation of scientific discoveries into improvise therapeutic outcomes. A key factor in the successful translation from bench to bedside is the accessibility and analysis of integrated data within and across functional domains. For example, most clinical and research data are currently stored in disparate and separate databases which is inefficient and inconvenient to access and retrieve these data. Therefore, translation bioinformatics serves as a platform to translate and bridge the gap between research and clinical practice. Translational bioinformatics incorporate informatics into scientific studies which allow data integration, standardization, categorization and management as well as resolving redundancies, inconsistencies and repetitions of representation of data. Translational bioinformatics not only allow effective...

Find Another Essay On What is Translational Bioinformatics?

What´s Protein Ontology? Essay

706 words - 3 pages Protein Ontology (PRO) is a curation that was designed as a Open Biomedical Ontologies (OBO) Discoveredry ontology for proteins. It contains information on the classification of proteins, evolutionary relationships and the multiple protein forms of a gene. These components include post-translational modifications, alternative splicing and cleavage. This paper focused on the TGF-beta signaling proteins and specifically described the usage

Research proposal on Genome Organization of a Rhizobacteria

857 words - 4 pages Introduction: Heavy metal pollution of soil is a significant environmental problem and has its adverse effect on human health and agriculture. Rhizosphere, as an important interface of soil and plant, plays a significant role in phytoremediation , in which, microbial populations are known to affect heavy metal mobility and availability to the plant [1] [2] through improve trace element solubility in the rhizosphere, release of organic acids

Is Animal Research Unethical?

603 words - 3 pages Animal Lab Spring 2014 Professor: Ashley Oneill In today’s society and modern medicine animals are extremely important in research, specifically translational research. Translational research is research that applies its findings to medical practices as well as a myriad of other fields in order to positively affect the subjects (Rubio et al. 470-475). Research cannot be done on humans due to moral reasons therefore animals are used. To ensure

Bioinformatics Knowledge Management Systems

2741 words - 11 pages , 2000) and from this we can infer that they are related. This is what gave rise to what we know now as the BKMS which is a system for managing knowledge in Bioinformatics. Because BKMS isn’t a very popular topic, it is somewhat difficult to find a great amount of research on it. When trying to discover details about KMS in Bioinformatics or Bioinformatics KM or anything similar to that, most of the time it is one subject or the other. However

Bioinformatics

2453 words - 10 pages I.Introduction When future generations reflect upon this current era of human history and development, it is almost certain that the birth and advancement of bioinformatics will be among the most awe-inspiring of topics. Bioinformatics is the field of study which is concerned with the storage, retrieval, and analysis of biological data via the tools of informatics. The two major objectives of bioinformatics (as identified by -new avenues-p9

statement of purpose

871 words - 4 pages Aiming to carve a niche for myself in this broad area of Computer Science I apply to the Masters in Computer Science Program in Jacobs School of Engineering at the University of California, San Diego. This is the Program and the University for me which matches in all aspects of what I seek. The buzz about the enabling environment within the Computer Science and Engineering Department, which requires students to push their limits and helps them

Bioinformatics, the Human Genome, and Their Consequences for the Human Population

1128 words - 5 pages work together in human health and disease.” The human genome is a field that scientists have been working in for approximately 25 years. Blood testing and crime scene investigation have been the main fields of bioinformatics. There are advantages and disadvantages to this new technology. Advantages include, knowing whether or not somebody is susceptible to a disease. This could change that person's feelings on a family or what

Translation Studies: The Skopos Theory

2129 words - 9 pages and purpose of the target text. He points out that Skopos theory belongs to the theory of translational action as translation is an act of communication based on the source text. Any action has a skopos and a result. For translational action in particular, the result is translatum, which is a specific variety of target text as defined by him. (Vermeer 1989 in Venuti 2004: 221) In addition, he suggests that the role of the source text in the

The Admissions Committee would like to learn why you are a good fit for your undergraduate school choice (College of Arts and Sciences, School of

635 words - 3 pages environment inside and out of the human body and many other organisms this combined with the present exponential momentum of computing, data storage and networking have made many people including scholars wonder where and what is achievable in the next fifty years. Now I must say I was pretty meticulous at first at the level of transformation we might experience in the future – for a long time I strongly believe that not much will change for

The Human Genome: Will It Change Your Life?

1110 words - 4 pages because I will inform the reader that deafness is a disease that can not only be detected through a physical examination, but, because of the use of genetics, we are able to microscopically see if that person will have the disease in the future. This is valuable information that will make the future better for many people.I also plan on using the article, "The Bioinformatics Goldrush," by Ken Howard in my research project. This article informs

The Importance Of Biotechnology In Today's Time

3554 words - 15 pages the Human Prospect. Washington, DC. American Chemical Society.9. Kumar, H.D. (2003). Modern Concepts of Biotechnology. New Delhi: Vikash Publishing House10. Lopez, D. A., R. M. Williams., and K. Michlke. (1994). Enzymes: The Foundation of Life. München: The Neville Press.11. Lund, Pete. "What is Bioinformatics?" Bioscience Course Manual, The University of Birmingham. pp: 3512. Purohit, S. (2005) Agricultural Biotechnology. India: Agrobios.13

Similar Essays

Study Of Bioinformatics, Proteomics, And Genomics

2125 words - 9 pages protected through the chemical base pairs sequencing that constitutes the DNA. It has thus provided us with the significant information as to how the genes interconnect and what sort of roles they carry out. With the knowledge of the genes interrelation treatments for most of the diseases are being discovered, there is no doubt that bioinformatics plays a significant role in this process (Deutschbauer M. & Chivian D., 2006). 2.1.3 Bioinformatics

I Provide Your Grandparents With Designer Drugs

1303 words - 5 pages way to create new drugs, and the bioinformatics companies get their money, but what, exactly, is it like to work for these bioinformatics companies? That's where I-Search came in. What a great way to learn about a career and figure out if it is what people say it is and complete an assignment at the same time.Stuart Webb, the CEO of Aber Genomic Computing in the UK, John Haynes, who works for StrataGem in New Mexico, and Sunshine Fuller, the

Advances In Text Mining For Biocurators

2144 words - 9 pages bioinformatics where ‘texts’ are ‘mined’ from literature. PubMed currently contains over 23 million citations, and this database is growing exponentially each year. With the huge scientific database growing each day, the interest in the ability to text mine also grows as it is hard to keep up-to-date with new discoveries. Scientists struggle to manually keep up to date with the literature in the database. This creates an urgent need for designed

Team Science A Concept Analysis

1838 words - 8 pages Fund, 2012). Given the sophistication and complexity of our public health, social, technological, and environmental problems, team science is generally referred to as the cross-disciplinary engagement and collaborations around the longer-term interaction of groups of investigators (Falk-Kzesinski et al., 2010; Kahn,1992; Kahn & Prager, 1999; Klein, 2008 ). The Institute for Translational Science definition of the SciTS is quite broad in scope